/* ------------------------------------------------------------------------
	Class: prettyPhoto
	Use: Lightbox clone for jQuery
	Author: Stephane Caron (http://www.no-margin-for-errors.com)
	Version: 3.1.6
------------------------------------------------------------------------- */
(function($) {
	$.prettyPhoto = {version: '3.1.6'};

	$.fn.prettyPhoto = function(pp_settings) {
		pp_settings = jQuery.extend({
			hook: 'rel', /* the attribute tag to use for prettyPhoto hooks. default: 'rel'. For HTML5, use "data-rel" or similar. */
			animation_speed: 'fast', /* fast/slow/normal */
			ajaxcallback: function() {},
			slideshow: 5000, /* false OR interval time in ms */
			autoplay_slideshow: false, /* true/false */
			opacity: 0.80, /* Value between 0 and 1 */
			show_title: true, /* true/false */
			allow_resize: true, /* Resize the photos bigger than viewport. true/false */
			allow_expand: true, /* Allow the user to expand a resized image. true/false */
			default_width: 500,
			default_height: 344,
			counter_separator_label: '/', /* The separator for the gallery counter 1 "of" 2 */
			theme: 'pp_default', /* light_rounded / dark_rounded / light_square / dark_square / facebook */
			horizontal_padding: 20, /* The padding on each side of the picture */
			hideflash: false, /* Hides all the flash object on a page, set to TRUE if flash appears over prettyPhoto */
			wmode: 'opaque', /* Set the flash wmode attribute */
			autoplay: true, /* Automatically start videos: True/False */
			modal: false, /* If set to true, only the close button will close the window */
			deeplinking: true, /* Allow prettyPhoto to update the url to enable deeplinking. */
			overlay_gallery: true, /* If set to true, a gallery will overlay the fullscreen image on mouse over */
			overlay_gallery_max: 30, /* Maximum number of pictures in the overlay gallery */
			keyboard_shortcuts: true, /* Set to false if you open forms inside prettyPhoto */
			changepicturecallback: function(){}, /* Called everytime an item is shown/changed */
			callback: function(){}, /* Called when prettyPhoto is closed */
			ie6_fallback: true,
			markup: '<div class="pp_pic_holder"> \
						<div class="ppt">&nbsp;</div> \
						<div class="pp_top"> \
							<div class="pp_left"></div> \
							<div class="pp_middle"></div> \
							<div class="pp_right"></div> \
						</div> \
						<div class="pp_content_container"> \
							<div class="pp_left"> \
							<div class="pp_right"> \
								<div class="pp_content"> \
									<div class="pp_loaderIcon"></div> \
									<div class="pp_fade"> \
										<a href="#" class="pp_expand" title="Expand the image">Expand</a> \
										<div class="pp_hoverContainer"> \
											<a class="pp_next" href="#">next</a> \
											<a class="pp_previous" href="#">previous</a> \
										</div> \
										<div id="pp_full_res"></div> \
										<div class="pp_details"> \
											<div class="pp_nav"> \
												<a href="#" class="pp_arrow_previous">Previous</a> \
												<p class="currentTextHolder">0/0</p> \
												<a href="#" class="pp_arrow_next">Next</a> \
											</div> \
											<p class="pp_description"></p> \
											<div class="pp_social">{pp_social}</div> \
											<a class="pp_close" href="#">Close</a> \
										</div> \
									</div> \
								</div> \
							</div> \
							</div> \
						</div> \
						<div class="pp_bottom"> \
							<div class="pp_left"></div> \
							<div class="pp_middle"></div> \
							<div class="pp_right"></div> \
						</div> \
					</div> \
					<div class="pp_overlay"></div>',
			gallery_markup: '<div class="pp_gallery"> \
								<a href="#" class="pp_arrow_previous">Previous</a> \
								<div> \
									<ul> \
										{gallery} \
									</ul> \
								</div> \
								<a href="#" class="pp_arrow_next">Next</a> \
							</div>',
			image_markup: '<img id="fullResImage" src="{path}" />',
			flash_markup: '<object classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" width="{width}" height="{height}"><param name="wmode" value="{wmode}" /><param name="allowfullscreen" value="true" /><param name="allowscriptaccess" value="always" /><param name="movie" value="{path}" /><embed src="{path}" type="application/x-shockwave-flash" allowfullscreen="true" allowscriptaccess="always" width="{width}" height="{height}" wmode="{wmode}"></embed></object>',
			quicktime_markup: '<object classid="clsid:02BF25D5-8C17-4B23-BC80-D3488ABDDC6B" codebase="https://www.apple.com/qtactivex/qtplugin.cab" height="{height}" width="{width}"><param name="src" value="{path}"><param name="autoplay" value="{autoplay}"><param name="type" value="video/quicktime"><embed src="{path}" height="{height}" width="{width}" autoplay="{autoplay}" type="video/quicktime" pluginspage="https://www.apple.com/quicktime/download/"></embed></object>',
			iframe_markup: '<iframe src ="{path}" width="{width}" height="{height}" frameborder="no"></iframe>',
			inline_markup: '<div class="pp_inline">{content}</div>',
			custom_markup: '',
			social_tools: '<div class="twitter"><a href="//twitter.com/share" class="twitter-share-button" data-count="none">Tweet</a><script type="text/javascript" src="//platform.twitter.com/widgets.js"></script></div><div class="facebook"><iframe src="//www.facebook.com/plugins/like.php?locale=en_US&href={location_href}&amp;layout=button_count&amp;show_faces=true&amp;width=500&amp;action=like&amp;font&amp;colorscheme=light&amp;height=23" scrolling="no" frameborder="0" style="border:none; overflow:hidden; width:500px; height:23px;" allowTransparency="true"></iframe></div>' /* html or false to disable */
		}, pp_settings);

		// Global variables accessible only by prettyPhoto
		var matchedObjects = this, percentBased = false, pp_dimensions, pp_open,

		// prettyPhoto container specific
		pp_contentHeight, pp_contentWidth, pp_containerHeight, pp_containerWidth,

		// Window size
		windowHeight = $(window).height(), windowWidth = $(window).width(),

		// Global elements
		pp_slideshow;

		doresize = true, scroll_pos = _get_scroll();

		// Window/Keyboard events
		$(window).off('resize.prettyphoto').on('resize.prettyphoto',function(){ _center_overlay(); _resize_overlay(); });

		if(pp_settings.keyboard_shortcuts) {
			$(document).off('keydown.prettyphoto').on('keydown.prettyphoto',function(e){
				if(typeof $pp_pic_holder != 'undefined'){
					if($pp_pic_holder.is(':visible')){
						switch(e.keyCode){
							case 37:
								$.prettyPhoto.changePage('previous');
								e.preventDefault();
								break;
							case 39:
								$.prettyPhoto.changePage('next');
								e.preventDefault();
								break;
							case 27:
								if(!settings.modal)
								$.prettyPhoto.close();
								e.preventDefault();
								break;
						};
						// return false;
					};
				};
			});
		};

		/**
		* Initialize prettyPhoto.
		*/
		$.prettyPhoto.initialize = function() {

			settings = pp_settings;

			if(settings.theme == 'pp_default') settings.horizontal_padding = 16;

			// Find out if the picture is part of a set
			theRel = $(this).attr(settings.hook);
			galleryRegExp = /\[(?:.*)\]/;
			isSet = (galleryRegExp.exec(theRel)) ? true : false;

			// Put the SRCs, TITLEs, ALTs into an array.
			pp_images = (isSet) ? jQuery.map(matchedObjects, function(n, i){ if($(n).attr(settings.hook).indexOf(theRel) != -1) return $(n).attr('href'); }) : $.makeArray($(this).attr('href'));
			pp_titles = (isSet) ? jQuery.map(matchedObjects, function(n, i){ if($(n).attr(settings.hook).indexOf(theRel) != -1) return ($(n).find('img').attr('alt')) ? $(n).find('img').attr('alt') : ""; }) : $.makeArray($(this).find('img').attr('alt'));
			pp_descriptions = (isSet) ? jQuery.map(matchedObjects, function(n, i){ if($(n).attr(settings.hook).indexOf(theRel) != -1) return ($(n).attr('title')) ? $(n).attr('title') : ""; }) : $.makeArray($(this).attr('title'));

			if(pp_images.length > settings.overlay_gallery_max) settings.overlay_gallery = false;

			set_position = jQuery.inArray($(this).attr('href'), pp_images); // Define where in the array the clicked item is positionned
			rel_index = (isSet) ? set_position : $("a["+settings.hook+"^='"+theRel+"']").index($(this));

			_build_overlay(this); // Build the overlay {this} being the caller

			if(settings.allow_resize)
				$(window).on('scroll.prettyphoto',function(){ _center_overlay(); });


			$.prettyPhoto.open();

			return false;
		}


		/**
		* Opens the prettyPhoto modal box.
		* @param image {String,Array} Full path to the image to be open, can also be an array containing full images paths.
		* @param title {String,Array} The title to be displayed with the picture, can also be an array containing all the titles.
		* @param description {String,Array} The description to be displayed with the picture, can also be an array containing all the descriptions.
		*/
		$.prettyPhoto.open = function(event) {
			if(typeof settings == "undefined"){ // Means it's an API call, need to manually get the settings and set the variables
				settings = pp_settings;
				pp_images = $.makeArray(arguments[0]);
				pp_titles = (arguments[1]) ? $.makeArray(arguments[1]) : $.makeArray("");
				pp_descriptions = (arguments[2]) ? $.makeArray(arguments[2]) : $.makeArray("");
				isSet = (pp_images.length > 1) ? true : false;
				set_position = (arguments[3])? arguments[3]: 0;
				_build_overlay(event.target); // Build the overlay {this} being the caller
			}

			if(settings.hideflash) $('object,embed,iframe[src*=youtube],iframe[src*=vimeo]').css('visibility','hidden'); // Hide the flash

			_checkPosition($(pp_images).length); // Hide the next/previous links if on first or last images.

			$('.pp_loaderIcon').show();

			if(settings.deeplinking)
				setHashtag();

			// Rebuild Facebook Like Button with updated href
			if(settings.social_tools){
				facebook_like_link = settings.social_tools.replace('{location_href}', encodeURIComponent(location.href));
				$pp_pic_holder.find('.pp_social').html(facebook_like_link);
			}

			// Fade the content in
			if($ppt.is(':hidden')) $ppt.css('opacity',0).show();
			$pp_overlay.show().fadeTo(settings.animation_speed,settings.opacity);

			// Display the current position
			$pp_pic_holder.find('.currentTextHolder').text((set_position+1) + settings.counter_separator_label + $(pp_images).length);

			// Set the description
			if(typeof pp_descriptions[set_position] != 'undefined' && pp_descriptions[set_position] != ""){
				$pp_pic_holder.find('.pp_description').show().html(unescape(pp_descriptions[set_position]));
			}else{
				$pp_pic_holder.find('.pp_description').hide();
			}

			// Get the dimensions
			movie_width = ( parseFloat(getParam('width',pp_images[set_position])) ) ? getParam('width',pp_images[set_position]) : settings.default_width.toString();
			movie_height = ( parseFloat(getParam('height',pp_images[set_position])) ) ? getParam('height',pp_images[set_position]) : settings.default_height.toString();

			// If the size is % based, calculate according to window dimensions
			percentBased=false;
			if(movie_height.indexOf('%') != -1) { movie_height = parseFloat(($(window).height() * parseFloat(movie_height) / 100) - 150); percentBased = true; }
			if(movie_width.indexOf('%') != -1) { movie_width = parseFloat(($(window).width() * parseFloat(movie_width) / 100) - 150); percentBased = true; }

			// Fade the holder
			$pp_pic_holder.fadeIn(function(){
				// Set the title
				(settings.show_title && pp_titles[set_position] != "" && typeof pp_titles[set_position] != "undefined") ? $ppt.html(unescape(pp_titles[set_position])) : $ppt.html('&nbsp;');

				imgPreloader = "";
				skipInjection = false;

				// Inject the proper content
				switch(_getFileType(pp_images[set_position])){
					case 'image':
						imgPreloader = new Image();

						// Preload the neighbour images
						nextImage = new Image();
						if(isSet && set_position < $(pp_images).length -1) nextImage.src = pp_images[set_position + 1];
						prevImage = new Image();
						if(isSet && pp_images[set_position - 1]) prevImage.src = pp_images[set_position - 1];

						$pp_pic_holder.find('#pp_full_res')[0].innerHTML = settings.image_markup.replace(/{path}/g,pp_images[set_position]);

						imgPreloader.onload = function(){
							// Fit item to viewport
							pp_dimensions = _fitToViewport(imgPreloader.width,imgPreloader.height);

							_showContent();
						};

						imgPreloader.onerror = function(){
							alert('Image cannot be loaded. Make sure the path is correct and image exist.');
							$.prettyPhoto.close();
						};

						imgPreloader.src = pp_images[set_position];
					break;

					case 'youtube':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport

						// Regular youtube link
						movie_id = getParam('v',pp_images[set_position]);

						// youtu.be link
						if(movie_id == ""){
							movie_id = pp_images[set_position].split('youtu.be/');
							movie_id = movie_id[1];
							if(movie_id.indexOf('?') > 0)
								movie_id = movie_id.substr(0,movie_id.indexOf('?')); // Strip anything after the ?

							if(movie_id.indexOf('&') > 0)
								movie_id = movie_id.substr(0,movie_id.indexOf('&')); // Strip anything after the &
						}

						movie = '//www.youtube.com/embed/'+movie_id;
						(getParam('rel',pp_images[set_position])) ? movie+="?rel="+getParam('rel',pp_images[set_position]) : movie+="?rel=1";

						if(settings.autoplay) movie += "&autoplay=1";

						toInject = settings.iframe_markup.replace(/{width}/g,pp_dimensions['width']).replace(/{height}/g,pp_dimensions['height']).replace(/{wmode}/g,settings.wmode).replace(/{path}/g,movie);
					break;

					case 'vimeo':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport

						movie_id = pp_images[set_position];
						var regExp = /http(s?):\/\/(www\.)?vimeo.com\/(\d+)/;
						var match = movie_id.match(regExp);

						movie = '//player.vimeo.com/video/'+ match[3] +'?title=0&amp;byline=0&amp;portrait=0';
						if(settings.autoplay) movie += "&autoplay=1;";

						vimeo_width = pp_dimensions['width'] + '/embed/?moog_width='+ pp_dimensions['width'];

						toInject = settings.iframe_markup.replace(/{width}/g,vimeo_width).replace(/{height}/g,pp_dimensions['height']).replace(/{path}/g,movie);
					break;

					case 'quicktime':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport
						pp_dimensions['height']+=15; pp_dimensions['contentHeight']+=15; pp_dimensions['containerHeight']+=15; // Add space for the control bar

						toInject = settings.quicktime_markup.replace(/{width}/g,pp_dimensions['width']).replace(/{height}/g,pp_dimensions['height']).replace(/{wmode}/g,settings.wmode).replace(/{path}/g,pp_images[set_position]).replace(/{autoplay}/g,settings.autoplay);
					break;

					case 'flash':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport

						flash_vars = pp_images[set_position];
						flash_vars = flash_vars.substring(pp_images[set_position].indexOf('flashvars') + 10,pp_images[set_position].length);

						filename = pp_images[set_position];
						filename = filename.substring(0,filename.indexOf('?'));

						toInject =  settings.flash_markup.replace(/{width}/g,pp_dimensions['width']).replace(/{height}/g,pp_dimensions['height']).replace(/{wmode}/g,settings.wmode).replace(/{path}/g,filename+'?'+flash_vars);
					break;

					case 'iframe':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport

						frame_url = pp_images[set_position];
						frame_url = frame_url.substr(0,frame_url.indexOf('iframe')-1);

						toInject = settings.iframe_markup.replace(/{width}/g,pp_dimensions['width']).replace(/{height}/g,pp_dimensions['height']).replace(/{path}/g,frame_url);
					break;

					case 'ajax':
						doresize = false; // Make sure the dimensions are not resized.
						pp_dimensions = _fitToViewport(movie_width,movie_height);
						doresize = true; // Reset the dimensions

						skipInjection = true;
						$.get(pp_images[set_position],function(responseHTML){
							toInject = settings.inline_markup.replace(/{content}/g,responseHTML);
							$pp_pic_holder.find('#pp_full_res')[0].innerHTML = toInject;
							_showContent();
						});

					break;

					case 'custom':
						pp_dimensions = _fitToViewport(movie_width,movie_height); // Fit item to viewport

						toInject = settings.custom_markup;
					break;

					case 'inline':
						// to get the item height clone it, apply default width, wrap it in the prettyPhoto containers , then delete
						myClone = $(pp_images[set_position]).clone().append('<br clear="all" />').css({'width':settings.default_width}).wrapInner('<div id="pp_full_res"><div class="pp_inline"></div></div>').appendTo($('body')).show();
						doresize = false; // Make sure the dimensions are not resized.
						pp_dimensions = _fitToViewport($(myClone).width(),$(myClone).height());
						doresize = true; // Reset the dimensions
						$(myClone).remove();
						toInject = settings.inline_markup.replace(/{content}/g,$(pp_images[set_position]).html());
					break;
				};

				if(!imgPreloader && !skipInjection){
					$pp_pic_holder.find('#pp_full_res')[0].innerHTML = toInject;

					// Show content
					_showContent();
				};
			});

			return false;
		};


		/**
		* Change page in the prettyPhoto modal box
		* @param direction {String} Direction of the paging, previous or next.
		*/
		$.prettyPhoto.changePage = function(direction){
			currentGalleryPage = 0;

			if(direction == 'previous') {
				set_position--;
				if (set_position < 0) set_position = $(pp_images).length-1;
			}else if(direction == 'next'){
				set_position++;
				if(set_position > $(pp_images).length-1) set_position = 0;
			}else{
				set_position=direction;
			};

			rel_index = set_position;

			if(!doresize) doresize = true; // Allow the resizing of the images
			if(settings.allow_expand) {
				$('.pp_contract').removeClass('pp_contract').addClass('pp_expand');
			}

			_hideContent(function(){ $.prettyPhoto.open(); });
		};


		/**
		* Change gallery page in the prettyPhoto modal box
		* @param direction {String} Direction of the paging, previous or next.
		*/
		$.prettyPhoto.changeGalleryPage = function(direction){
			if(direction=='next'){
				currentGalleryPage ++;

				if(currentGalleryPage > totalPage) currentGalleryPage = 0;
			}else if(direction=='previous'){
				currentGalleryPage --;

				if(currentGalleryPage < 0) currentGalleryPage = totalPage;
			}else{
				currentGalleryPage = direction;
			};

			slide_speed = (direction == 'next' || direction == 'previous') ? settings.animation_speed : 0;

			slide_to = currentGalleryPage * (itemsPerPage * itemWidth);

			$pp_gallery.find('ul').animate({left:-slide_to},slide_speed);
		};


		/**
		* Start the slideshow...
		*/
		$.prettyPhoto.startSlideshow = function(){
			if(typeof pp_slideshow == 'undefined'){
				$pp_pic_holder.find('.pp_play').off('click').removeClass('pp_play').addClass('pp_pause').on( 'click', function(){
					$.prettyPhoto.stopSlideshow();
					return false;
				});
				pp_slideshow = setInterval($.prettyPhoto.startSlideshow,settings.slideshow);
			}else{
				$.prettyPhoto.changePage('next');
			};
		}


		/**
		* Stop the slideshow...
		*/
		$.prettyPhoto.stopSlideshow = function(){
			$pp_pic_holder.find('.pp_pause').off('click').removeClass('pp_pause').addClass('pp_play').on( 'click', function(){
				$.prettyPhoto.startSlideshow();
				return false;
			});
			clearInterval(pp_slideshow);
			pp_slideshow=undefined;
		}


		/**
		* Closes prettyPhoto.
		*/
		$.prettyPhoto.close = function(){
			if($pp_overlay.is(":animated")) return;

			$.prettyPhoto.stopSlideshow();

			$pp_pic_holder.stop().find('object,embed').css('visibility','hidden');

			$('div.pp_pic_holder,div.ppt,.pp_fade').fadeOut(settings.animation_speed,function(){ $(this).remove(); });

			$pp_overlay.fadeOut(settings.animation_speed, function(){

				if(settings.hideflash) $('object,embed,iframe[src*=youtube],iframe[src*=vimeo]').css('visibility','visible'); // Show the flash

				$(this).remove(); // No more need for the prettyPhoto markup

				$(window).off('scroll.prettyphoto');

				clearHashtag();

				settings.callback();

				doresize = true;

				pp_open = false;

				delete settings;
			});
		};

		/**
		* Set the proper sizes on the containers and animate the content in.
		*/
		function _showContent(){
			$('.pp_loaderIcon').hide();

			// Calculate the opened top position of the pic holder
			projectedTop = scroll_pos['scrollTop'] + ((windowHeight/2) - (pp_dimensions['containerHeight']/2));
			if(projectedTop < 0) projectedTop = 0;

			$ppt.fadeTo(settings.animation_speed,1);

			// Resize the content holder
			$pp_pic_holder.find('.pp_content')
				.animate({
					height:pp_dimensions['contentHeight'],
					width:pp_dimensions['contentWidth']
				},settings.animation_speed);

			// Resize picture the holder
			$pp_pic_holder.animate({
				'top': projectedTop,
				'left': ((windowWidth/2) - (pp_dimensions['containerWidth']/2) < 0) ? 0 : (windowWidth/2) - (pp_dimensions['containerWidth']/2),
				width:pp_dimensions['containerWidth']
			},settings.animation_speed,function(){
				$pp_pic_holder.find('.pp_hoverContainer,#fullResImage').height(pp_dimensions['height']).width(pp_dimensions['width']);

				$pp_pic_holder.find('.pp_fade').fadeIn(settings.animation_speed); // Fade the new content

				// Show the nav
				if(isSet && _getFileType(pp_images[set_position])=="image") { $pp_pic_holder.find('.pp_hoverContainer').show(); }else{ $pp_pic_holder.find('.pp_hoverContainer').hide(); }

				if(settings.allow_expand) {
					if(pp_dimensions['resized']){ // Fade the resizing link if the image is resized
						$('a.pp_expand,a.pp_contract').show();
					}else{
						$('a.pp_expand').hide();
					}
				}

				if(settings.autoplay_slideshow && !pp_slideshow && !pp_open) $.prettyPhoto.startSlideshow();

				settings.changepicturecallback(); // Callback!

				pp_open = true;
			});

			_insert_gallery();
			pp_settings.ajaxcallback();
		};

		/**
		* Hide the content...DUH!
		*/
		function _hideContent(callback){
			// Fade out the current picture
			$pp_pic_holder.find('#pp_full_res object,#pp_full_res embed').css('visibility','hidden');
			$pp_pic_holder.find('.pp_fade').fadeOut(settings.animation_speed,function(){
				$('.pp_loaderIcon').show();

				callback();
			});
		};

		/**
		* Check the item position in the gallery array, hide or show the navigation links
		* @param setCount {integer} The total number of items in the set
		*/
		function _checkPosition(setCount){
			(setCount > 1) ? $('.pp_nav').show() : $('.pp_nav').hide(); // Hide the bottom nav if it's not a set.
		};

		/**
		* Resize the item dimensions if it's bigger than the viewport
		* @param width {integer} Width of the item to be opened
		* @param height {integer} Height of the item to be opened
		* @return An array containin the "fitted" dimensions
		*/
		function _fitToViewport(width,height){
			resized = false;

			_getDimensions(width,height);

			// Define them in case there's no resize needed
			imageWidth = width, imageHeight = height;

			if( ((pp_containerWidth > windowWidth) || (pp_containerHeight > windowHeight)) && doresize && settings.allow_resize && !percentBased) {
				resized = true, fitting = false;

				while (!fitting){
					if((pp_containerWidth > windowWidth)){
						imageWidth = (windowWidth - 200);
						imageHeight = (height/width) * imageWidth;
					}else if((pp_containerHeight > windowHeight)){
						imageHeight = (windowHeight - 200);
						imageWidth = (width/height) * imageHeight;
					}else{
						fitting = true;
					};

					pp_containerHeight = imageHeight, pp_containerWidth = imageWidth;
				};



				if((pp_containerWidth > windowWidth) || (pp_containerHeight > windowHeight)){
					_fitToViewport(pp_containerWidth,pp_containerHeight)
				};

				_getDimensions(imageWidth,imageHeight);
			};

			return {
				width:Math.floor(imageWidth),
				height:Math.floor(imageHeight),
				containerHeight:Math.floor(pp_containerHeight),
				containerWidth:Math.floor(pp_containerWidth) + (settings.horizontal_padding * 2),
				contentHeight:Math.floor(pp_contentHeight),
				contentWidth:Math.floor(pp_contentWidth),
				resized:resized
			};
		};

		/**
		* Get the containers dimensions according to the item size
		* @param width {integer} Width of the item to be opened
		* @param height {integer} Height of the item to be opened
		*/
		function _getDimensions(width,height){
			width = parseFloat(width);
			height = parseFloat(height);

			// Get the details height, to do so, I need to clone it since it's invisible
			$pp_details = $pp_pic_holder.find('.pp_details');
			$pp_details.width(width);
			detailsHeight = parseFloat($pp_details.css('marginTop')) + parseFloat($pp_details.css('marginBottom'));

			$pp_details = $pp_details.clone().addClass(settings.theme).width(width).appendTo($('body')).css({
				'position':'absolute',
				'top':-10000
			});
			detailsHeight += $pp_details.height();
			detailsHeight = (detailsHeight <= 34) ? 36 : detailsHeight; // Min-height for the details
			$pp_details.remove();

			// Get the titles height, to do so, I need to clone it since it's invisible
			$pp_title = $pp_pic_holder.find('.ppt');
			$pp_title.width(width);
			titleHeight = parseFloat($pp_title.css('marginTop')) + parseFloat($pp_title.css('marginBottom'));
			$pp_title = $pp_title.clone().appendTo($('body')).css({
				'position':'absolute',
				'top':-10000
			});
			titleHeight += $pp_title.height();
			$pp_title.remove();

			// Get the container size, to resize the holder to the right dimensions
			pp_contentHeight = height + detailsHeight;
			pp_contentWidth = width;
			pp_containerHeight = pp_contentHeight + titleHeight + $pp_pic_holder.find('.pp_top').height() + $pp_pic_holder.find('.pp_bottom').height();
			pp_containerWidth = width;
		}

		function _getFileType(itemSrc){
			if (itemSrc.match(/youtube\.com\/watch/i) || itemSrc.match(/youtu\.be/i)) {
				return 'youtube';
			}else if (itemSrc.match(/vimeo\.com/i)) {
				return 'vimeo';
			}else if(itemSrc.match(/\b.mov\b/i)){
				return 'quicktime';
			}else if(itemSrc.match(/\b.swf\b/i)){
				return 'flash';
			}else if(itemSrc.match(/\biframe=true\b/i)){
				return 'iframe';
			}else if(itemSrc.match(/\bajax=true\b/i)){
				return 'ajax';
			}else if(itemSrc.match(/\bcustom=true\b/i)){
				return 'custom';
			}else if(itemSrc.substr(0,1) == '#'){
				return 'inline';
			}else{
				return 'image';
			};
		};

		function _center_overlay(){
			if(doresize && typeof $pp_pic_holder != 'undefined') {
				scroll_pos = _get_scroll();
				contentHeight = $pp_pic_holder.height(), contentwidth = $pp_pic_holder.width();

				projectedTop = (windowHeight/2) + scroll_pos['scrollTop'] - (contentHeight/2);
				if(projectedTop < 0) projectedTop = 0;

				if(contentHeight > windowHeight)
					return;

				$pp_pic_holder.css({
					'top': projectedTop,
					'left': (windowWidth/2) + scroll_pos['scrollLeft'] - (contentwidth/2)
				});
			};
		};

		function _get_scroll(){
			if (self.pageYOffset) {
				return {scrollTop:self.pageYOffset,scrollLeft:self.pageXOffset};
			} else if (document.documentElement && document.documentElement.scrollTop) { // Explorer 6 Strict
				return {scrollTop:document.documentElement.scrollTop,scrollLeft:document.documentElement.scrollLeft};
			} else if (document.body) {// all other Explorers
				return {scrollTop:document.body.scrollTop,scrollLeft:document.body.scrollLeft};
			};
		};

		function _resize_overlay() {
			windowHeight = $(window).height(), windowWidth = $(window).width();

			if(typeof $pp_overlay != "undefined") $pp_overlay.height($(document).height()).width(windowWidth);
		};

		function _insert_gallery(){
			if(isSet && settings.overlay_gallery && _getFileType(pp_images[set_position])=="image") {
				itemWidth = 52+5; // 52 beign the thumb width, 5 being the right margin.
				navWidth = (settings.theme == "facebook" || settings.theme == "pp_default") ? 50 : 30; // Define the arrow width depending on the theme

				itemsPerPage = Math.floor((pp_dimensions['containerWidth'] - 100 - navWidth) / itemWidth);
				itemsPerPage = (itemsPerPage < pp_images.length) ? itemsPerPage : pp_images.length;
				totalPage = Math.ceil(pp_images.length / itemsPerPage) - 1;

				// Hide the nav in the case there's no need for links
				if(totalPage == 0){
					navWidth = 0; // No nav means no width!
					$pp_gallery.find('.pp_arrow_next,.pp_arrow_previous').hide();
				}else{
					$pp_gallery.find('.pp_arrow_next,.pp_arrow_previous').show();
				};

				galleryWidth = itemsPerPage * itemWidth;
				fullGalleryWidth = pp_images.length * itemWidth;

				// Set the proper width to the gallery items
				$pp_gallery
					.css('margin-left',-((galleryWidth/2) + (navWidth/2)))
					.find('div:first').width(galleryWidth+5)
					.find('ul').width(fullGalleryWidth)
					.find('li.selected').removeClass('selected');

				goToPage = (Math.floor(set_position/itemsPerPage) < totalPage) ? Math.floor(set_position/itemsPerPage) : totalPage;

				$.prettyPhoto.changeGalleryPage(goToPage);

				$pp_gallery_li.filter(':eq('+set_position+')').addClass('selected');
			}else{
				$pp_pic_holder.find('.pp_content').off('mouseenter mouseleave');
				// $pp_gallery.hide();
			}
		}

		function _build_overlay(caller){
			// Inject Social Tool markup into General markup
			if(settings.social_tools)
				facebook_like_link = settings.social_tools.replace('{location_href}', encodeURIComponent(location.href));

			settings.markup = settings.markup.replace('{pp_social}','');

			$('body').append(settings.markup); // Inject the markup

			$pp_pic_holder = $('.pp_pic_holder') , $ppt = $('.ppt'), $pp_overlay = $('div.pp_overlay'); // Set my global selectors

			// Inject the inline gallery!
			if(isSet && settings.overlay_gallery) {
				currentGalleryPage = 0;
				toInject = "";
				for (var i=0; i < pp_images.length; i++) {
					if(!pp_images[i].match(/\b(jpg|jpeg|png|gif)\b/gi)){
						classname = 'default';
						img_src = '';
					}else{
						classname = '';
						img_src = pp_images[i];
					}
					toInject += "<li class='"+classname+"'><a href='#'><img src='" + img_src + "' width='50' alt='' /></a></li>";
				};

				toInject = settings.gallery_markup.replace(/{gallery}/g,toInject);

				$pp_pic_holder.find('#pp_full_res').after(toInject);

				$pp_gallery = $('.pp_pic_holder .pp_gallery'), $pp_gallery_li = $pp_gallery.find('li'); // Set the gallery selectors

				$pp_gallery.find('.pp_arrow_next').on( 'click', function(){
					$.prettyPhoto.changeGalleryPage('next');
					$.prettyPhoto.stopSlideshow();
					return false;
				});

				$pp_gallery.find('.pp_arrow_previous').on( 'click', function(){
					$.prettyPhoto.changeGalleryPage('previous');
					$.prettyPhoto.stopSlideshow();
					return false;
				});

				$pp_pic_holder.find('.pp_content').on( 'mouseenter',
					function(){
						$pp_pic_holder.find('.pp_gallery:not(.disabled)').fadeIn();
					} ).on( 'mouseleave',
					function(){
						$pp_pic_holder.find('.pp_gallery:not(.disabled)').fadeOut();
					});

				itemWidth = 52+5; // 52 beign the thumb width, 5 being the right margin.
				$pp_gallery_li.each(function(i){
					$(this)
						.find('a')
						.on( 'click', function(){
							$.prettyPhoto.changePage(i);
							$.prettyPhoto.stopSlideshow();
							return false;
						});
				});
			};


			// Inject the play/pause if it's a slideshow
			if(settings.slideshow){
				$pp_pic_holder.find('.pp_nav').prepend('<a href="#" class="pp_play">Play</a>')
				$pp_pic_holder.find('.pp_nav .pp_play').on( 'click', function(){
					$.prettyPhoto.startSlideshow();
					return false;
				});
			}

			$pp_pic_holder.attr('class','pp_pic_holder ' + settings.theme); // Set the proper theme

			$pp_overlay
				.css({
					'opacity':0,
					'height':$(document).height(),
					'width':$(window).width()
					})
				.on('click',function(){
					if(!settings.modal) $.prettyPhoto.close();
				});

			$('a.pp_close').on('click',function(){ $.prettyPhoto.close(); return false; });


			if(settings.allow_expand) {
				$('a.pp_expand').on('click',function(e){
					// Expand the image
					if($(this).hasClass('pp_expand')){
						$(this).removeClass('pp_expand').addClass('pp_contract');
						doresize = false;
					}else{
						$(this).removeClass('pp_contract').addClass('pp_expand');
						doresize = true;
					};

					_hideContent(function(){ $.prettyPhoto.open(); });

					return false;
				});
			}

			$pp_pic_holder.find('.pp_previous, .pp_nav .pp_arrow_previous').on('click',function(){
				$.prettyPhoto.changePage('previous');
				$.prettyPhoto.stopSlideshow();
				return false;
			});

			$pp_pic_holder.find('.pp_next, .pp_nav .pp_arrow_next').on('click',function(){
				$.prettyPhoto.changePage('next');
				$.prettyPhoto.stopSlideshow();
				return false;
			});

			_center_overlay(); // Center it
		};

		if(!pp_alreadyInitialized && getHashtag()){
			pp_alreadyInitialized = true;

			// Grab the rel index to trigger the click on the correct element
			hashIndex = getHashtag();
			hashRel = hashIndex;
			hashIndex = hashIndex.substring(hashIndex.indexOf('/')+1,hashIndex.length-1);
			hashRel = hashRel.substring(0,hashRel.indexOf('/'));

			// Little timeout to make sure all the prettyPhoto initialize scripts has been run.
			// Useful in the event the page contain several init scripts.
			setTimeout(function(){ $("a["+pp_settings.hook+"^='"+hashRel+"']:eq("+hashIndex+")").trigger('click'); },50);
		}

		return this.off('click.prettyphoto').on('click.prettyphoto',$.prettyPhoto.initialize); // Return the jQuery object for chaining. The unbind method is used to avoid click conflict when the plugin is called more than once
	};

	function getHashtag(){
		var url = location.href;
		hashtag = (url.indexOf('#prettyPhoto') !== -1) ? decodeURI(url.substring(url.indexOf('#prettyPhoto')+1,url.length)) : false;
		if(hashtag){  hashtag = hashtag.replace(/<|>/g,''); }
		return hashtag;
	};

	function setHashtag(){
		if(typeof theRel == 'undefined') return; // theRel is set on normal calls, it's impossible to deeplink using the API
		location.hash = theRel + '/'+rel_index+'/';
	};

	function clearHashtag(){
		if ( location.href.indexOf('#prettyPhoto') !== -1 ) location.hash = "prettyPhoto";
	}

	function getParam(name,url){
	  name = name.replace(/[\[]/,"\\\[").replace(/[\]]/,"\\\]");
	  var regexS = "[\\?&]"+name+"=([^&#]*)";
	  var regex = new RegExp( regexS );
	  var results = regex.exec( url );
	  return ( results == null ) ? "" : results[1];
	}

})(jQuery);

var pp_alreadyInitialized = false; // Used for the deep linking to make sure not to call the same function several times.

<main class="site-main post-30307 post type-post status-publish format-standard hentry category-public" role="main">
			<header class="page-header">
			<h1 class="entry-title">Etické aspekty vývoje a testování léčivých přípravků</h1>		</header>
		<div class="page-content">
		<p>Etické aspekty vývoje a testování léčivých přípravků</p>
<h3>Úvod do etických aspektů ve farmaceutickém vývoji</h3>
<p>Vývoj a testování léčivých přípravků je komplexní proces, který zahrnuje nejen vědecké a technické výzvy, ale také hluboké etické otázky nan. Etické aspekty hrají klíčovou roli při rozhodování o tom, jaké metody a postupy budou použity během výzkumu a testování nových léků. Při zvažování těchto aspektů je důležité mít na paměti, že cílem je nejen vytvořit účinné léky, ale také respektovat lidskou důstojnost a práva. Proces zahrnuje různé fáze, od laboratorních studií až po klinické zkoušky na lidech, a každá fáze vyžaduje pečlivé zvážení etických principů.</p>
<p>Jedním z klíčových aspektů je zajištění, že všechny experimenty prováděné na lidech jsou eticky odůvodněné a prováděné s plným souhlasem účastníků. To zahrnuje nejen poskytnutí jasných informací o možných rizicích a přínosech, ale také respektování práva účastníků kdykoliv z výzkumu odstoupit. Etické standardy vyžadují, aby byly experimenty navrženy tak, aby minimalizovaly rizika a maximalizovaly potenciální přínosy. Důležitým zdrojem informací o etice ve farmaceutickém průmyslu je například <a href='https://lekarna-viktorie.com/produkt/fml-forte/'>https://lekarna-viktorie.com/produkt/fml-forte/</a>, kde lze nalézt mnoho užitečných informací.</p>
<h3>Role vědecké integrity a transparentnosti</h3>
<p>Vědecká integrita a transparentnost jsou klíčovými komponentami etického vývoje léčivých přípravků. Vědecká integrita znamená, že veškeré fáze výzkumu a testování jsou prováděny s maximální přesností a bez úmyslného zkreslování výsledků. Transparentnost pak zajišťuje, že všechny zúčastněné strany mají přístup k relevantním informacím, což je důležité pro důvěru veřejnosti i odborné komunity.</p>
<p>Transparentní komunikace výsledků výzkumu je zásadní pro zajištění důvěry veřejnosti. To zahrnuje zveřejňování jak pozitivních, tak negativních výsledků, aby bylo možné objektivně posoudit účinnost a bezpečnost nově vyvíjených léčiv. Transparentnost také podporuje spolupráci mezi různými výzkumnými týmy a institucemi, což může vést k rychlejšímu pokroku a inovacím v oblasti farmacie.</p>
<h3>Význam etických komisí a regulačních orgánů</h3>
<p>Etické komise a regulační orgány hrají rozhodující roli při zajišťování, že vývoj a testování léčivých přípravků probíhá podle nejvyšších etických standardů. Tyto orgány poskytují nezávislý dozor a hodnocení výzkumných projektů, čímž zajišťují ochranu práv a bezpečnosti účastníků. Etické komise často zahrnují odborníky z různých oborů, kteří mohou poskytnout různé pohledy na etické otázky.</p>
<p>Regulační orgány, jako jsou například Evropská léková agentura nebo Úřad pro kontrolu potravin a léčiv v USA, stanovují pravidla a normy pro vývoj a testování léčiv. Tyto orgány nejenže dohlížejí na dodržování etických standardů, ale také zajišťují, že nové léky splňují požadované bezpečnostní a účinnostní parametry. Jejich role je klíčová pro ochranu veřejného zdraví.</p>
<h3>Etické aspekty a jejich vliv na společnost</h3>
<p>Etické aspekty vývoje a testování léčiv mají hluboký dopad na společnost jako celek. Dobře navržené a eticky prováděné studie mohou vést k vývoji nových, účinných léků, které mohou výrazně zlepšit kvalitu života pacientů. Naopak zanedbání etických standardů může vést k nedůvěře veřejnosti a poškození reputace farmaceutických společností.</p>
<p>Etické otázky se také týkají dostupnosti a cenové dostupnosti nových léků. Společnost očekává, že inovace ve zdravotnictví budou dostupné všem, kteří je potřebují, a to za přijatelnou cenu. Diskuse o etice ve farmaceutickém průmyslu tedy zahrnuje nejen otázky týkající se vývoje a testování, ale také distribuce a přístupu k léčivým přípravkům.</p>
<h3>Informace o webu lekarna-viktorie.com</h3>
<p>Webová stránka lekarna-viktorie.com je důležitým zdrojem informací pro všechny, kdo se zajímají o vývoj a testování léčivých přípravků. Poskytuje aktuální informace o různých léčivech, jejich účinnosti a bezpečnosti. Stránka je navržena tak, aby návštěvníkům poskytla snadný přístup k potřebným informacím a umožnila jim informovaně rozhodnout o svém zdraví.</p>
<p>Kromě informací o konkrétních produktech, jako je FML Forte, nabízí web také články a aktuality týkající se etických aspektů a regulačních změn ve farmaceutickém průmyslu. Tímto způsobem přispívá k lepšímu porozumění složitému procesu vývoje léčiv a podporuje zodpovědné a etické jednání v této oblasti.</p>
		<div class="post-tags">
					</div>
			</div>